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Prostate Cancer

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发表于 2011-8-24 15:56:43 | 显示全部楼层 |阅读模式
本帖最后由 东方阳 于 2011-8-24 15:57 编辑

What is prostate cancer?

Prostate cancer starts in the cells of the prostate gland. The prostate is part of the male reproductive system. Its main function is to make part of the liquid (seminal fluid) that mixes with sperm from the testicles to make semen. Semen is ejaculated during sex.
The prostate is about the size of a large walnut. It is located close to the rectum just below the bladder at the base of the penis. The prostate surrounds the urethra, the tube that carries urine and semen through the penis.
Prostate cancer is the most common cancer in Canadian men. It usually grows slowly and can often be cured or managed successfully.

  

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 楼主| 发表于 2011-8-24 15:58:15 | 显示全部楼层
Causes of prostate cancer
There is no single cause of prostate cancer, but some factors appear to increase the risk of developing it. The risk of prostate cancer increases as men grow older. Having these risk factors doesn’t mean that you will develop prostate cancer. It means that your chances of developing it are higher.
You may be at higher risk if you:
·                     age – being older than 65  
·                     family history of prostate cancer
·                     African ancestry
Eating a diet high in fat and working with a metal called cadmium are being studied as possible risk factors. Eating a diet high in calcium is also being studied as a possible risk factor. Calcium has many health benefits, and research so far tells us that the levels of calcium have to be very high – much higher than in the average man’s diet – for it to be a concern.
It is possible to develop prostate cancer without having any of these risk factors.
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 楼主| 发表于 2011-8-24 15:58:49 | 显示全部楼层
When is it time to talk?
It’s time to talk with your doctor if you’re a man and you:
·                     will soon be 50 years old
·                     are over 50 and you haven’t talked about prostate cancer with your doctor yet
·                     may be at a higher risk of developing prostate cancer because you have a family history or if you are of African ancestry
·                     have symptoms of prostate cancer
If your doctor hasn’t talked to you about your prostate health and your risk for prostate cancer, the information on our web pages can help you get the conversation started.
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 楼主| 发表于 2011-8-24 15:59:18 | 显示全部楼层
Tests for prostate cancer
Your doctor can check your prostate for signs of cancer before you have any symptoms.  
There are 2 tests available to help detect prostate cancer early.
·                     Digital rectal exam (DRE): a physical examination of the prostate gland through the rectum. The doctor inserts a gloved finger into the rectum to feel the prostate for lumps or anything else that seems unusual.
·                     Prostate-specific antigen (PSA) test: a blood test that measures prostate-specific antigen, a substance made by the prostate. The normal level of PSA changes as you get older. Higher levels of PSA can be caused by several prostate problems, not just cancer. Sometimes men with prostate cancer have PSA levels that are not higher than normal.
No test for detecting cancer is 100% accurate. But, using these tests together is better than using either test alone. If a problem is found, more tests will be done to find out whether you have prostate cancer or another health problem. Further tests can include:
·                     follow-up PSA test
·                     transrectal ultrasound (TRUS): a test that uses sound waves to make a picture of the rectum and nearby organs, including the prostate.
·                     biopsy of the prostate: a tissue sample of the prostate to be examined under a microscope.
Normal PSA levels by age
This table shows the normal range of PSA levels in each age group.
Age range  (years)
Normal total PSA  range
40–49
0.0–2.5
50–59
0.0–3.5
60–69
0.0–4.5
70–79
0.0–6.5
Reasons for having a higher than normal PSA level
PSA levels may be higher than normal for your age for many reasons, such as:
·                     enlarged prostate (benign prostatic hyperplasia)
·                     inflamed prostate (prostatitis)
·                     medical test on the prostate (such as biopsy or transrectal ultrasound)
·                     cancer cells in the prostate
No specific PSA level can confirm if you have cancer or not. But a high PSA level may suggest that cancer is present. More tests will be needed to confirm a diagnosis of cancer.
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 楼主| 发表于 2011-8-24 15:59:46 | 显示全部楼层
Signs and symptoms of prostate cancer
Prostate cancer may not cause any signs or symptoms, especially in the early stages. It may be found when you’ve had a PSA test or digital rectal  examination. Symptoms may appear if the tumour makes the prostate larger than normal and it starts to press on the urethra. This can make passing urine more difficult or painful or you may need to go more often.  
As a man gets older, the prostate may become enlarged and block the urethra or bladder. This is a common condition called benign prostatic hyperplasia (BPH). BPH is not cancer, but the symptoms of BPH are similar to the symptoms of prostate cancer. Testing is needed to confirm a diagnosis.
Don't ignore symptoms
If you have any of these symptoms, don't ignore them. See your doctor. You may need to have some tests to help find out what is causing them. Most enlargements of the prostate are not cancer.
Signs and symptoms for prostate cancer are:
·                     need to urinate often, especially at night
·                     intense need to urinate (urgency)
·                     difficulty in starting or stopping the urine flow
·                     inability to urinate
·                     weak, decreased or interrupted urine stream
·                     a sense of incompletely emptying the bladder
·                     burning or pain during urination
·                     blood in the urine or semen
·                     painful ejaculation
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 楼主| 发表于 2011-8-24 16:00:12 | 显示全部楼层
Staging and grading for prostate cancer
Once a definite diagnosis of cancer has been made and your healthcare team has the information it needs, the cancer will be given a stage and a grade.
The cancer stage describes the tumour size and tells whether it has spread beyond the place where it started to grow. For prostate cancer, there are four stages.
Stage
Description
1
Cancer is found in the prostate only.
2
Cancer is larger than stage 1, but is still found only in the prostate.
3
Cancer has spread outside the prostate but not to nearby organs.
4
Cancer has spread to nearby organs, lymph nodes or distant parts of the body.
To find out the grade of a tumour, the biopsy sample is examined under a microscope. A grade is given based on how the cancer cells look and behave compared to normal cells. This can give your healthcare team an idea of how quickly the cancer may be growing and how likely it is to spread.
For prostate cancer, the grade is usually given as a Gleason score from 2 to 10. A low Gleason score means the cancer cells are similar to normal prostate cells. A high Gleason score means the cancer cells are very different from normal cells. Most prostate cancer tumours are moderate grade.
Grade
Gleason score
Description
1
2–4
Low grade – slow growing, less likely to spread
2
5–7
Moderate grade – grow slightly faster than grade 1 and may spread
3
8–10
High grade – tend to grow quickly, more likely to spread
It is important to know the stage and grade of the cancer and your PSA level. This information helps you and your healthcare team choose the best treatment for you.
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 楼主| 发表于 2011-8-24 16:00:39 | 显示全部楼层
Treatment for prostate cancer
Active surveillance
Some prostate cancers are very slow growing and can be present for years without affecting your health. Your healthcare team will watch the cancer closely. Your doctor will examine your prostate and test your PSA levels regularly. A TRUS or biopsy may be done from time to time. Immediate treatment may be considered only if signs of cancer appear or change.If immediate treatment is recommended, you might receive one or more of the following treatments.
Surgery
A decision to have surgery depends on the stage and grade of the cancer, your general health and your PSA level. During the operation, the entire prostate will be removed. This is called a prostatectomy. Some nearby tissue may also be affected by the surgery. Surgery is done under general anesthetic (you will be unconscious) and you may stay in the hospital for several days after the surgery.
After surgery, you will have a narrow tube called a catheter in your bladder, but this is usually removed within a few days. You may have some pain or nausea, or may not feel like eating. These side effects are temporary and can be controlled. Surgery to the prostate can damage the nerves that control your ability to have or keep an erection (impotence). When possible, nerve-sparing surgery will be used to try to avoid nerve damage. After prostate surgery you may have problems controlling your bladder (incontinence). Problems with incontinence usually improve with time.
Radiation therapy
In external beam radiation therapy, a large machine is used to carefully aim a beam of radiation at the prostate. The radiation damages the cells in the path of the beam – normal cells as well as cancer cells. In brachytherapy, or internal radiation therapy, radioactive beads or seeds are placed directly into or near the prostate.
Side effects will be different depending on what part of the body receives the radiation. You may feel more tired than usual, have diarrhea, or notice changes to the skin (it may be red or tender) where the treatment was given. Radiation for prostate cancer may irritate the rectum and cause changes to your bowel movements. You may also need to pass urine more often. These side effects are a result of damage to normal cells. The side effects will usually improve or go away when the treatment period is over and the normal cells repair themselves.
Hormonal therapy
Hormonal therapy is a treatment that removes or blocks hormones and stops cancer cells from growing. Prostate cancer needs the male hormone testosterone to grow. Hormonal therapy gets rid of testosterone or lowers the level of testosterone in your body to slow the growth of the tumour and to shrink it.
The level of testosterone in the body can be lowered by surgically removing the testicles (bilateral orchiectomy) or by using drugs. Hormonal drugs can be given as pills or injections, or both. Today, it is more common to use drugs to lower testosterone than it is to remove the testicles.
Hormonal drug therapy may cause some side effects in some men. Different drugs cause different side effects, such as hot flashes, impotence, loss of desire for sex, weight gain or breast tenderness. Your bones may become weaker. These effects can usually be reduced or controlled. They often go away when therapy is finished.
Chemotherapy
Chemotherapy may be given as pills or by injection. Chemotherapy drugs interfere with the ability of cancer cells to grow and spread, but they also damage healthy cells. Although healthy cells can recover over time, you may experience side effects from your treatment like nausea, vomiting, loss of appetite, fatigue, hair loss and an increased risk of infection.Chemotherapy is not used to treat cancer of the prostate in the early stages of the disease.
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发表于 2011-9-16 15:02:57 | 显示全部楼层
这个嘛,要枕边人多点检查嘛。
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