Nobel prize for Canadian-born scientist to stand despite his death

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Sheryl Ubelacker, Monday, October 03, 2011 2:19 PM

In this April 24, 2009 photo, Canadian-born Dr. Ralph Steinman of Rockefeller University speaks during a news conference in Albany, N.Y., Friday, April 24, 2009. Three scientists won the Nobel Prize in medicine on Monday for discoveries about the immune system that opened new avenues for the treatment and prevention of infectious illnesses and cancer.American Bruce Beutler and French scientist Jules Hoffmann shared the 10 million-kronor ($1.5 million) award with Canadian-born Ralph Steinman, the Nobel committee at Stockholm's Karolinska institute said. THE CANADIAN PRESS/AP, Mike Groll

The Nobel Foundation says the decision to award the Nobel Prize in medicine to Canadian-born cell biologist Ralph Steinman will stand, even though he died three days before the announcement.

In what seems a particularly cruel twist of fate, Steinman was awarded the coveted award Monday — three days after he had died of pancreatic cancer at age 68.

The Nobel committee had been unaware of Steinman's death Friday when it announced he was to share the prize with two other researchers.

Since 1974, the Nobel statutes don't allow posthumous awards unless a laureate dies after the announcement but before the Dec. 10 award ceremony.

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However, after an emergency meeting Monday, the Swedish foundation said the prize would remain, saying: "The Nobel Prize to Ralph Steinman was made in good faith, based on the assumption that the Nobel laureate was alive."

Montreal-born Steinman was cited by the Nobel committee for his discoveries about the immune system. He shares the 10-million kronor (C$1.5 million) award with American Bruce Beutler and Jules Hoffmann of France.

A statement from Rockefeller University in New York, where the cell biologist had carried out his research since 1970, said Steinman had been treated with immunotherapy based on his discovery of dendritic cells. These cells help regulate adaptive immunity, an immune system response that purges invading micro-organisms from the body.

"He was diagnosed with pancreatic cancer four years ago, and his life was extended using a dendritic-cell based immunotherapy of his own design," the university said.

In Stockholm, Nobel committee member Goran Hansson said the committee didn't know Steinman had died when it chose him as a winner.

"It is incredibly sad news," Hansson said. "We can only regret that he didn't have the chance to receive the news he had won the Nobel Prize. Our thoughts are now with his family."

Nobel officials said they believe it is the first time a laureate has died before the announcement without the committee's knowledge.
Steinman, recently given a gleaming new lab in his role as head of Rockefeller University's Center for Immunology and Immune Diseases, has received many recognitions for his work, including the Albert Lasker Award for Basic Medical Research in 2007 and the Canadian Gairdner Award in 2003.

"For several years, we've been wondering and hoping that Ralph Steinman might be winning the Nobel Prize, and today when I heard that he won it, I was delighted," said Dr. Lorne Tyrrell of the University of Alberta, chair of the Gairdner Foundation board that selected him as a winner.

"And then I felt cheated and ... it was such a cruel turn of fate to find out that he passed away on Friday, because I think nothing would have made him happier near the end of his life, to have heard that he won the Nobel Prize," Tyrrell said from Kyoto, Japan, where he was attending a conference.

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Dr. John Dirks, Gairdner Foundation president and scientific director, said Steinman was a great researcher who knew his science and critiqued it well.
"He liked Canada a lot, loved Canada — his family is still here in large part — and just a great person and almost an ideal image of a creative scientist," Dirks said in an interview from Japan.
"We'll miss him in every respect. I can't imagine how sad this is — just a few minutes before everyone hears of this great honour and the next moment we realize that he died over the weekend."
Alan Bernstein, a fellow Canadian who got to know Steinman during his 3 1/2-year tenure as head of the Global HIV Vaccine Enterprise in New York, said he was shocked and saddened to hear of the death of his friend and colleague.

Bernstein said Steinman took him under his scientific wing when he first arrived in New York in 2008 and the two would celebrate Canada Day together each year.

"Ralph was a wonderful human being, so his passing, aside from the Nobel, is very sad news indeed. He was a very warm-hearted individual, very open," Bernstein said Monday from Fethiye, Turkey, where he on vacation.

"And it's very sad that he, I assume, never lived to hear the wonderful news. Knowing Ralph as I do, while it would have been nice for him to hear it, I suspect it wouldn't have been so important as you might think, in the sense that he cared most about the science."

Steinman's discovery dates back to 1973, when he found a new cell type, the dendritic cell, which has a unique capacity to activate T-cells. Those cells have a key role in adaptive immunity, when antibodies and killer cells fight infections. They also develop a memory that helps the immune system mobilize its defences next time it comes under a similar attack.

The Nobel committee also cited Beutler and Hoffmann for their discoveries in the 1990s of receptor proteins that can recognize bacteria and other micro-organisms as they enter the body, and activate the first line of defence in the immune system, known as innate immunity.

The trio's discoveries have enabled the development of improved vaccines against infectious diseases. In the long term they could also yield better treatments of cancer, rheumatoid arthritis, type 1 diabetes, multiple sclerosis, and chronic inflammatory diseases, Hansson said.

The discoveries have helped scientists understand why the immune system sometimes attacks its own tissues, paving the way for new ways to fight inflammatory diseases, Hansson said.

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"They have made possible the development of new methods for preventing and treating disease, for instance with improved vaccines against infections and in attempts to stimulate the immune system to attack tumours," the committee said.

No vaccines are on the market yet, but Hansson said that vaccines against hepatitis are in the pipeline.

"Large clinical trials are being done today," he said.
Beutler, 53, is professor of genetics and immunology at the Scripps Research Institute in San Diego, Calif. Hoffmann, 70, headed a research laboratory in Strasbourg, France, between 1974 and 2009 and served as president of the French National Academy of Sciences between 2007-2008.

Hoffmann's discovery came in 1996 during research on how fruit flies fight infections. Two years later, Beutler's research on mice showed that fruit flies and mammals activate innate immunity in similar ways when attacked by germs.
The medicine award kicked off a week of Nobel Prize announcements, and will be followed by the physics prize on Tuesday, chemistry on Wednesday, literature on Thursday and the Nobel Peace Prize on Friday. The winners of the economics award will be announced Oct. 10.

The prizes were established by wealthy Swedish industrialist Alfred Nobel — the inventor of dynamite — except for the economics award, which was created by Sweden's central bank in 1968 in Nobel's memory. The prizes are always handed out Dec. 10, on the anniversary of Nobel's death in 1896.

Last year's medicine award went to British professor Robert Edwards for fertility research that led to the first test tube baby.
— With files from The Associated Press.


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从来就没救世主

Nobel prize 只给活人，这次能不能破例？

东方阳

从来就没救世主 发表于 2011-10-4 09:17
Nobel prize 只给活人，这次能不能破例？

这次已经破例了。“The Nobel Foundation says the decision to award the Nobel Prize in medicine to Canadian-born cell biologist Ralph Steinman will stand, even though he died three days before the announcement.”